2976-0526 2976-0526 S2976-05262025000300003 10.71749/pkj.103 Portugal Portugal Portugal Portugal Portugal Portugal Portugal Portugal Portugal Portugal Portugal Portugal Portugal Portugal Portugal Portugal Portugal Portugal Portugal Portugal Portugal 00 09 2025 00 09 2025 39 3 3 11

1 2010 363 221-32 2 2020 382 622-31 3 2021 325 2178-87 4 ADVOCATE Study Group 2021 384 599-609 5 Food and Drug Administration, fda.gov. 6 Health Canada, Canada.ca. 7 2022 81 315-20 8 2023 19 1-5 9 2024 9 1783-91 10 2019 34 63-73 11 2021 7 624-8 12 2024 8 rkae100 13 2025 19 23-37 14 2025 107 558-67 15 2025 64 2019-26 16 2022 16 432-6