<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2795-5001</journal-id>
<journal-title><![CDATA[Portuguese Journal of Dermatology and Venereology]]></journal-title>
<abbrev-journal-title><![CDATA[Port J Dermatol Venereol.]]></abbrev-journal-title>
<issn>2795-5001</issn>
<publisher>
<publisher-name><![CDATA[Permanyer Publications]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2795-50012023000300205</article-id>
<article-id pub-id-type="doi">10.24875/pjdv.23000016</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Titanium hypersensitivity in a patient with a titanium medical implant]]></article-title>
<article-title xml:lang="pt"><![CDATA[Hipersensibilidade ao titânio num doente com um implante médico de titânio]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lopes]]></surname>
<given-names><![CDATA[Ana G.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pereira]]></surname>
<given-names><![CDATA[Teresa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guimarães]]></surname>
<given-names><![CDATA[Maria J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cerqueira]]></surname>
<given-names><![CDATA[Catarina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gomes]]></surname>
<given-names><![CDATA[Joana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Brito]]></surname>
<given-names><![CDATA[Celeste]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital of Braga Dermatology Department ]]></institution>
<addr-line><![CDATA[Braga ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2023</year>
</pub-date>
<volume>81</volume>
<numero>3</numero>
<fpage>205</fpage>
<lpage>208</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.pt/scielo.php?script=sci_arttext&amp;pid=S2795-50012023000300205&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.pt/scielo.php?script=sci_abstract&amp;pid=S2795-50012023000300205&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.pt/scielo.php?script=sci_pdf&amp;pid=S2795-50012023000300205&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract A 53-year-old male patient with priors of psoriasis suffered a left tibial plateau fracture and underwent open reduction and internal fixation with a titanium plating system. He had no history of atopy or contact-hypersensitivity reactions to metals. Almost 1 year later, the patient continued to have chronic pain and edema at the site of the implant. On examination, the patient had a well-healed surgical incision on the left leg without erythema or induration but with tenderness to touch and two fluctuating nodular lesions. Subsequent allergy patch testing revealed an allergy-positive reaction to nickel sulfate, titanium oxalate and sodium tetrachloropalladate. The patient was diagnosed with titanium hypersensitivity secondary to recent implantation. The patient underwent hardware removal with a resolution of the complaints. The allergic risk of titanium material is smaller than that of other metal materials. Positive patch test reactions to titanium are rare and a negative patch does not exclude the diagnosis. Preimplant patients should be asked about a history of hypersensitivity reactions to metals and patch testing should be recommended for those who have experienced such reactions.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo Descreve-se o caso de um doente do sexo masculino de 53 anos, com antecedentes pessoais de psoríase, que sofreu uma fratura do prato tibial esquerdo, e foi submetido a uma redução aberta e fixação interna fixação interna com um implante de titânio. O doente não referia história prévia de atopia ou reações de hipersensibilidade a metais. Um ano após a cirurgia, o doente mantinha queixas de dor crónica e edema no local do implante. Ao exame dermatológico, era visível uma incisão cirúrgica linear bem cicatrizada na perna esquerda, sem eritema ou endurecimento, mas com aumento da sensibilidade ao toque e com 2 lesões nodulares móveis. Testes epicutâneos revelaram uma reação alérgica positiva ao sulfato de níquel, oxalato de titânio e tetracloropaladato de sódio. O doente foi diagnosticado com hipersensibilidade ao titânio secundário à recente colocação do implante de titânio na perna. O doente foi submetido a extração do material, com resolução das queixas. O risco de alergia ao titânio é mais pequeno do que com qualquer outro metal. Reações positivas nos testes epicutâneos são raras e um teste negativo não exclui o diagnóstico. Os doentes que vão ser submetidos a cirurgias para colocação de implantes metálicos devem ser questionados acerca de história pessoal passada de reações de hipersensibilidade a metais e os testes epicutâneos pré-operatórios devem ser recomendados àqueles que têm estes antecedentes.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Allergy]]></kwd>
<kwd lng="en"><![CDATA[Medical implant]]></kwd>
<kwd lng="en"><![CDATA[Patch testing]]></kwd>
<kwd lng="en"><![CDATA[Titanium]]></kwd>
<kwd lng="en"><![CDATA[Titanium hypersensitivity]]></kwd>
<kwd lng="pt"><![CDATA[Alergia]]></kwd>
<kwd lng="pt"><![CDATA[Hipersensibilidade ao titânio]]></kwd>
<kwd lng="pt"><![CDATA[Implante médico]]></kwd>
<kwd lng="pt"><![CDATA[Testes epicutâneos]]></kwd>
<kwd lng="pt"><![CDATA[Titânio]]></kwd>
</kwd-group>
</article-meta>
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