<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0871-9721</journal-id>
<journal-title><![CDATA[Revista Portuguesa de Imunoalergologia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Port Imunoalergologia]]></abbrev-journal-title>
<issn>0871-9721</issn>
<publisher>
<publisher-name><![CDATA[Sociedade Portuguesa de Alergologia e Imunologia Clínica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0871-97212023000100065</article-id>
<article-id pub-id-type="doi">10.32932/rpia.2023.03.105</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Anafilaxia a clorohexidina - Uma complicação incomum após algaliação]]></article-title>
<article-title xml:lang="en"><![CDATA[Chlorhexidine anaphylaxis - A complication after urinary Catheterization]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Falcão]]></surname>
<given-names><![CDATA[Inês]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Marques]]></surname>
<given-names><![CDATA[Maria Luís]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Falcão]]></surname>
<given-names><![CDATA[Helena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Hospitalar Universitário do Porto Serviço de Imunoalergologia ]]></institution>
<addr-line><![CDATA[Porto ]]></addr-line>
<country>Portugal</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital da Senhora da Oliveira Serviço de Imunoalergologia ]]></institution>
<addr-line><![CDATA[Guimarães ]]></addr-line>
<country>Portugal</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2023</year>
</pub-date>
<volume>31</volume>
<numero>1</numero>
<fpage>65</fpage>
<lpage>70</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.pt/scielo.php?script=sci_arttext&amp;pid=S0871-97212023000100065&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.pt/scielo.php?script=sci_abstract&amp;pid=S0871-97212023000100065&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.pt/scielo.php?script=sci_pdf&amp;pid=S0871-97212023000100065&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO A clorohexidina (CHX) é um antissético com amplo espetro de atividade antibacteriana e antifúngica e por isso um dos mais utilizados nos cuidados de saúde e na comunidade. A verdadeira incidência de hipersensibilidade à CHX permanece desconhecida; vários estudos indicam uma incidência que varia de 5,5 a 8,8% em doentes com reação perioperatória, porém dados recentes apontam para uma tendência crescente. Os autores reportam o caso clínico de uma anafilaxia perioperatória num homem de 76 anos após algaliação com um cateter urinário de látex e um lubrificante anestésico contendo CHX. Após estudo em consulta de Imunoalergologia, recorrendo a testes in vivo e in vitro, foi diagnosticado com alergia à CHX. O objetivo deste caso clínico é alertar a comunidade médico-cirúrgica para a ubiquidade deste antissético e como por vezes é um alergénio esquecido e oculto em diversos produtos de uso perioperatório e deve fazer parte da investigação dos casos de anafilaxia neste contexto.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Chlorhexidine (CHX) is an antiseptic with a broad spectrum antibacterial and antifungal activity, having become ubiquitous in healthcare and in the community. The true incidence of CHX hypersensitivity remains unknown, several studies indicate to an incidence between 5,5 to 8,8%. However, recent data point to a growing trend. The authors report the case of a 76-year-old man who, after catheterization with a latex urinary catheter and a lubricant containing CHX, developed anaphylaxis. After evaluation in Immunoallergology consultation, using in vivo and in vitro tests, he was diagnosed with CHX allergy. The objective of this clinical case is to alert the healthcare community to the ubiquity of this antiseptic and how it is sometimes a forgotten and hidden allergen in several peri and postoperative products and therefore should be part of the investigation of anaphylaxis cases in this context.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Alergia]]></kwd>
<kwd lng="pt"><![CDATA[anafilaxia]]></kwd>
<kwd lng="pt"><![CDATA[antissético]]></kwd>
<kwd lng="pt"><![CDATA[clorohexidina]]></kwd>
<kwd lng="pt"><![CDATA[hipersensibilidade]]></kwd>
<kwd lng="en"><![CDATA[Allergy]]></kwd>
<kwd lng="en"><![CDATA[anaphylaxis]]></kwd>
<kwd lng="en"><![CDATA[antiseptic]]></kwd>
<kwd lng="en"><![CDATA[chlorhexidine]]></kwd>
<kwd lng="en"><![CDATA[hypersensitivity]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Opstrup]]></surname>
<given-names><![CDATA[MS]]></given-names>
</name>
<name>
<surname><![CDATA[Jemec]]></surname>
<given-names><![CDATA[GBE]]></given-names>
</name>
<name>
<surname><![CDATA[Garvey]]></surname>
<given-names><![CDATA[LH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chlorhexidine allergy: On the rise and often overlooked]]></article-title>
<source><![CDATA[Curr Allergy Asthma Rep]]></source>
<year>2019</year>
<volume>19</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>23</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nakonechna]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Dore]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Dixon]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Khan]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Deacock]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Holding]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Immediate hypersensitivity to chlorhexidine is increasingly recognised in the United Kingdom]]></article-title>
<source><![CDATA[Allergol Immunopathol]]></source>
<year>2014</year>
<volume>42</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>44-9</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sharp]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Green]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Rose]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chlorhexidine-induced anaphylaxis in surgical patients: A review of the literature]]></article-title>
<source><![CDATA[ANZ J Surg]]></source>
<year>2016</year>
<volume>86</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>237-43</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fernandes]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Lourenço]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Lopes]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Spínola Santos]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Pereira Santos]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Pereira Barbosa]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chlorhexidine: a hidden life-threatening allergen]]></article-title>
<source><![CDATA[Asia Pac Allergy]]></source>
<year>2019</year>
<volume>9</volume>
<numero>4</numero>
<issue>4</issue>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mueller-Wirth]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Buenter]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Jörg]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Ebo]]></surname>
<given-names><![CDATA[DG]]></given-names>
</name>
<name>
<surname><![CDATA[Glatz]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Fernando]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[IgE-mediated chlorhexidine allergy: Cross-reactivity with other biguanide disinfectants]]></article-title>
<source><![CDATA[Allergy]]></source>
<year>2020</year>
<volume>75</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>3237-47</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ebo]]></surname>
<given-names><![CDATA[DG]]></given-names>
</name>
<name>
<surname><![CDATA[Bridts]]></surname>
<given-names><![CDATA[CH]]></given-names>
</name>
<name>
<surname><![CDATA[Stevens]]></surname>
<given-names><![CDATA[WJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[IgE-mediated anaphylaxis from chlorhexidine: diagnostic possibilities]]></article-title>
<source><![CDATA[Contact Dermatitis]]></source>
<year>2006</year>
<volume>55</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>301-2</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Opstrup]]></surname>
<given-names><![CDATA[MS]]></given-names>
</name>
<name>
<surname><![CDATA[Malling]]></surname>
<given-names><![CDATA[HJ]]></given-names>
</name>
<name>
<surname><![CDATA[Krøigaard]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Mosbech]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Skov]]></surname>
<given-names><![CDATA[PS]]></given-names>
</name>
<name>
<surname><![CDATA[Poulsen]]></surname>
<given-names><![CDATA[LK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Standardized testing with chlorhexidine in perioperative allergy: A large single-centre evaluation]]></article-title>
<source><![CDATA[Allergy]]></source>
<year>2014</year>
<volume>69</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>1390-6</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brockow]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Garvey]]></surname>
<given-names><![CDATA[LH]]></given-names>
</name>
<name>
<surname><![CDATA[Aberer]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Atanaskovic-Markovic]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Barbaud]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bilo]]></surname>
<given-names><![CDATA[MB]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[ENDA/EAACI Drug Allergy Interest Group. Skin test concentrations for systemically administered drugs - an ENDA/EAACI Drug Allergy Interest Group position paper]]></article-title>
<source><![CDATA[Allergy]]></source>
<year>2013</year>
<volume>68</volume>
<page-range>702-12</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Odedra]]></surname>
<given-names><![CDATA[KM]]></given-names>
</name>
<name>
<surname><![CDATA[Farooque]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chlorhexidine: An unrecognised cause of anaphylaxis]]></article-title>
<source><![CDATA[Postgrad Med J]]></source>
<year>2014</year>
<volume>90</volume>
<page-range>709-14</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Toletone]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Dini]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Massa]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Bragazzi]]></surname>
<given-names><![CDATA[NL]]></given-names>
</name>
<name>
<surname><![CDATA[Pignatti]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Voltolini]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Durando]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chlorhexidine-induced anaphylaxis occurring in the workplace in a health-care worker: Case report and review of the literature]]></article-title>
<source><![CDATA[Med Lav]]></source>
<year>2018</year>
<volume>109</volume>
<page-range>68-76</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sharp]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Green]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Rose]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chlorhexidine-induced anaphylaxis in surgical patients: A review of the literature]]></article-title>
<source><![CDATA[ANZ J Surg]]></source>
<year>2016</year>
<volume>86</volume>
<page-range>237-43</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pemberton]]></surname>
<given-names><![CDATA[MN]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Allergy to chlorhexidine]]></article-title>
<source><![CDATA[Dent Update]]></source>
<year>2016</year>
<volume>43</volume>
<page-range>272-4</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chiewchalermsri]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Sompornrattanaphan]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Wongsa]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Thongngarm]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chlorhexidine allergy: Current challenges and future prospects]]></article-title>
<source><![CDATA[J Asthma Allergy]]></source>
<year>2020</year>
<volume>13</volume>
<page-range>127-33</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[AF]]></given-names>
</name>
<name>
<surname><![CDATA[Alpan]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Hoffmann]]></surname>
<given-names><![CDATA[HJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Basophil activation test: Mechanisms and considerations for use in clinical trials and clinical practice]]></article-title>
<source><![CDATA[Allergy]]></source>
<year>2021</year>
<volume>76</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>2420-32</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
