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Late Colon Involvement by Lobular Carcinoma of the Breast: A Diagnosis to Keep in Mind!

Envolvimento tardio do cólon por carcinoma lobular da mama: um diagnóstico a considerar

 

Miguel Bispo^a, Ricardo Rio-Tinto^a, Paulo Fidalgo^a, Mireia Castillo-Martin^b, Jacques Devière^a,c

^aDepartment of Gastroenterology and Digestive Endoscopy, Champalimaud Foundation, Lisbon, Portugal; ^bDepartment of Pathology, Champalimaud Foundation, Lisbon, Portugal; ^cDepartment of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium

^* Corresponding author.

 

Keywords: Breast cancer, Invasive lobular carcinoma, Colonic metastases

Palavras-chave: Cancro da mama, Carcinoma lobular invasivo, Metástases do cólon

 

Breast cancer is a heterogeneous disease with two main types: invasive ductal carcinoma (the most frequent type) and invasive lobular carcinoma (that comprises approximately 10% of all cases) [1, 2]. Lobular carcinoma is more than just a histologic variant of breast cancer, since it has distinct molecular, morphologic, biologic, and epidemiologic characteristics, which have clinical and prognostic implications [2].

We report the case of a 60-year-old female with a medical history of invasive lobular carcinoma of the breast 12 years before. At that time, the patient was submitted to resection surgery and adjuvant chemotherapy. Recurrence- free survival was documented for 12 years. Due to recent onset of chronic diarrhea and weight loss, colonoscopy was performed and documented diffuse edema involving the right colon and the ileocecal valve with asymmetric thickening/hypertrophy and rigidity of the folds, without ulceration (Fig. 1). Pathology identified diffuse infiltration of the lamina propria by scattered small and homogeneous cells, with a immunohistochemistry profile consistent with primary lobular carcinoma of the breast (Fig. 2). Computed tomography documented peritoneal and right colon involvement with ascites. The patient is currently under palliative chemotherapy, with a favorable response on computed tomography evaluation.

 

 

 

Invasive lobular carcinoma of the breast has a less predictable pattern of metastatic spread than ductal carcinoma, frequently involving unusual sites such as the gastrointestinal tract (stomach, small bowel, and colon), the ovary, and the peritoneum [2–4]. Although lobular carcinoma usually has a more favorable response to therapy and a longer recurrence-free survival compared to ductal carcinoma, recurrence may occur more than 10 years following therapy [3]. In case series of colorectal metastases from lobular breast cancer, the average interval between the diagnosis of the primary tumor and colonic involvement was 7 years, but late recurrence, as late as 17 years following the diagnosis of the primary tumor, in resemblance to the present case report, have been previously reported [5, 6]. An exceedingly late recurrence of lobular breast cancer presenting with gastric metastasis 23 years after the initial diagnosis and treatment has recently been described [7]. The infiltrating pattern of this tumor with scattered non-cohesive cells that lack cellular atypia infiltrating the submucosa, may result in false-negative results from endoscopic biopsies and delay the diagnosis [3, 5]. Keeping in mind the peculiar characteristics of invasive lobular carcinoma of the breast regarding gastrointestinal involvement might increase the diagnostic yield for its detection and allow prompt initiation of therapy.

 

References

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4 Mathew A, Rajagopal PS, Villgran V, Sandhu GS, Jankowitz RC, Jacob M, et al. Distinct Pattern of Metastases in Patients with Invasive Lobular Carcinoma of the Breast. Geburtshilfe Frauenheilkd. 2017 Jun;77(6):660–6.         [ Links ]

5 Amin AA, Reddy A, Jha M, et al. Rectal metastasis from breast cancer: an interval of 17 years. BMJ Case Rep. 2011 May 12;2011.pii: bcr0120113683.         [ Links ]

6 López Deogracias M, Flores Jaime L, Arias-Camisón I, Zamacola I, Murillo Guibert J, Suescun García R, et al. Rectal metastasis from lobular breast carcinoma 15 years after primary diagnosis. Clin Transl Oncol. 2010 Feb;12(2):150–3.         [ Links ]

7 Libânio D, Dinis-Ribeiro M, Pimentel-Nunes P. Gastric Metastasis of Breast Cancer after 20 Years. GE Port J Gastroenterol. 2018 Mar;25(2):99–101.         [ Links ]

 

Statement of Ethics

The authors have no ethical conflicts to disclose.

Disclosure Statement

The authors have no financial disclosures to report.

 

^* Corresponding author.

Miguel Bispo

Department of Gastroenterology and Digestive Endoscopy

Champalimaud Foundation, Av. Brasília

PT–1349-019 Lisbon (Portugal)

E-Mail miguel.bispo@fundacaochampalimaud.pt

 

Received: January 8, 2019; Accepted after revision: January 31, 2019